Blar i forfatter "Wilsgård, line"

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    • Effect of lower-leg trauma and knee arthroscopy on procoagulant phospholipid-dependent activity 

      Touw, Carolina E.; Nemeth, Banne; Lijfering, Willem M.; van Adrichem, Raymond A.; Wilsgård, line; Latysheva, Nadezhda; Ramberg, Cathrine; Nelissen, Rob G. H. H.; Hansen, John Bjarne; Cannegieter, Suzanne C. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-08)
      Background: Lower-leg injury and knee arthroscopy are both associated with venous thromboembolism (VTE). The mechanism of VTE in both situations is unknown, including the role of procoagulant microparticles. This may provide useful information for individualizing thromboprophylactic treatment in both patient groups.<p> <p>Objective: We aimed to study the effect of (1) lower-leg trauma and (2) ...

    • A modified clot-based assay to measure negatively charged procoagulant phospholipids 

      Ramberg, Cathrine; Jamaly, Simin; Latysheva, Nadezhda; Wilsgård, line; Sovershaev, Timofey; Snir, Omri; Hansen, Jesper (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-29)
      Growing evidence supports a role for extracellular vesicles (EVs) in haemostasis and thrombosis due to exposure of negatively charged procoagulant phospholipids (PPL). Current commercial PPL-dependent clotting assays use chemically phospholipid depleted plasma to measure PPL activity. The purpose of our study was to modify the PPL assay by substituting the chemically phospholipid depleted plasma ...

    • Plasma levels of platelet-derived microvesicles are associated with risk of future venous thromboembolism 

      Snir, Omri; Wilsgård, line; Latysheva, Nadezhda; Ullsten-Wahlund, Casper; Brækkan, Sigrid Kufaas; Hindberg, Kristian Dalsbø; Hansen, John Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-18)
      Background - Microvesicles (MVs) are small double‐membrane encapsulated particles shed from cells. Case‐control studies have reported elevated plasma levels of platelet‐derived MVs (PDMVs) in patients with venous thromboembolism (VTE). However, it is not known whether high PDMV levels is a risk factor or a consequence of the acute VTE event.<p> <p>Objectives - To investigate the association between ...

    • Plasma procoagulant phospholipid clotting time and venous thromboembolism risk 

      Ramberg, Cathrine; Wilsgård, line; Latysheva, Nadezhda; Brækkan, Sigrid Kufaas; Hindberg, Kristian; Sovershaev, Timofey; Snir, Omri; Hansen, John Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-20)
      Background - Negatively charged procoagulant phospholipids, phosphatidylserine (PS) in particular, are vital to coagulation and expressed on the surface membrane of extracellular vesicles. No previous study has investigated the association between plasma procoagulant phospholipid clotting time (PPL<sub>CT</sub>) and future risk of venous thromboembolism (VTE).<p> <p>Objectives - To investigate the ...